Anti-tumor necrosis factor- therapies attenuate adaptive arteriogenesis in the rabbit
نویسندگان
چکیده
Sebastian Grundmann,* Imo Hoefer,* Susann Ulusans, Niels van Royen, Stephan H. Schirmer, C. Keith Ozaki, Christoph Bode, Jan J. Piek, and Ivo Buschmann Department for Internal Medicine III (Cardiology and Angiology), University Hospital Freiburg, Freiburg, Germany; Department of Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam; Department of Experimental Cardiology, University Medical Center, Utrecht, The Netherlands; and University of Florida College of Medicine, Malcom Randall Veterans Affairs Medical Center, Gainesville, Florida
منابع مشابه
Endothelial-specific transgenesis of TNFR2 promotes adaptive arteriogenesis and angiogenesis.
OBJECTIVE We have previously shown that the tumor necrosis factor receptor 2 (TNFR2) protein is highly upregulated in vascular endothelium in response to ischemia, and a global deletion of TNFR2 in mice blunts ischemia-induced arteriogenesis and angiogenesis. However, the role of endothelial TNFR2 is not defined. In this study, we used endothelial cell (EC)-specific transgenesis of TNFR2 (TNFR2...
متن کاملEffect of ascorbic acid and alpha-tocopherol supplementations on serum leptin, tumor necrosis factor alpha, and serum amyloid A levels in individuals with type 2 diabetes mellitus
Objective: Diabetes mellitus Type 2 is one of the most widespread chronic metabolic diseases. In most cases, this type of diabetes is associated with alterations in levels of some inflammatory cytokines and hormones. Considering anti-inflammatory properties of plant extracts rich in ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E), anti-diabetic properties of these two well-known anti...
متن کاملIsolation and Characterization of Novel Phage Displayed scFv Fragment for Human Tumor Necrosis Factor Alpha and Molecular Docking Analysis of Their Interactions
Tumor necrosis factor alpha (TNF-α) expression amplifies to excess amounts in several disorders such as rheumatoid arthritis and psoriasis. Although, Anti-TNF biologics have revolutionized the treatment of these autoimmune diseases, formation of anti-drug antibodies (ADA) has dramatically affected their use. The next generation antibodies (e.g. Fab, scFv) have not only reduced resulted immunoge...
متن کاملIsolation and Characterization of Novel Phage Displayed scFv Fragment for Human Tumor Necrosis Factor Alpha and Molecular Docking Analysis of Their Interactions
Tumor necrosis factor alpha (TNF-α) expression amplifies to excess amounts in several disorders such as rheumatoid arthritis and psoriasis. Although, Anti-TNF biologics have revolutionized the treatment of these autoimmune diseases, formation of anti-drug antibodies (ADA) has dramatically affected their use. The next generation antibodies (e.g. Fab, scFv) have not only reduced resulted immunoge...
متن کاملTumor necrosis factor and anti-tumor necrosis factor therapies.
Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-...
متن کامل